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Warianty genetyczne receptora typu I z klasy B

Warianty genetyczne receptora typu I z klasy B

Katharina Winter

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786630355550
72,02 €
IVA incluido
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Sobre IBD

Receptor typu B, podtyp I (SR-BI) odgrywa kluczową rolę w metabolizmie lipoprotein o wysokiej gęstości (HDL). Jego zasadnicze znaczenie w wychwytywaniu cholesterolu i odwrotnym transporcie cholesterolu (RCT) zostało potwierdzone w kilku badaniach na myszach. Rola SR-BI u ludzi pozostaje niejasna. U pacjentów z podwyższonym poziomem cholesterolu HDL wykryto nowo opisaną mutację missense genu SR-BI (P297S). Naszym celem było zbadanie wpływu tej mutacji na interakcję między SR-BI a HDL.

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