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Variantes génétiques du récepteur scavenger de classe B de type I

Variantes génétiques du récepteur scavenger de classe B de type I

Katharina Winter

72,08 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786630368352
72,08 €
IVA incluido
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Sobre IBD

Le récepteur scavenger de classe B de type I (SR-BI) joue un rôle central dans le métabolisme des lipoprotéines de haute densité (HDL). Son rôle majeur dans l’absorption du cholestérol et le transport inverse du cholestérol (RCT) a été confirmé par plusieurs études menées chez la souris. Le rôle du SR-BI chez l’homme reste toutefois à préciser. Une mutation faux-sens récemment décrite du SR-BI (P297S) a été mise en évidence chez des patients présentant des taux élevés de cholestérol HDL. Notre objectif était d’étudier l’influence de cette mutation sur l’interaction entre le SR-BI et les HDL.

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