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Varianti genetiche del recettore scavenger di classe B, tipo I

Varianti genetiche del recettore scavenger di classe B, tipo I

Katharina Winter

72,02 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786630358117
72,02 €
IVA incluido
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Sobre IBD

Il recettore scavenger di classe B tipo I (SR-BI) svolge un ruolo centrale nel metabolismo delle lipoproteine ad alta densità (HDL). Il suo ruolo fondamentale nell’assorbimento del colesterolo e nel trasporto inverso del colesterolo (RCT) è stato confermato in diversi studi condotti sui topi. Il ruolo dell’SR-BI nell’uomo non è ancora chiaro. Una mutazione missenso dell’SR-BI (P297S), recentemente descritta, è stata riscontrata in pazienti con livelli elevati di colesterolo HDL. Il nostro obiettivo era quello di studiare l’influenza di questa mutazione sull’interazione tra l’SR-BI e l’HDL.

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