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Studio dell’attività antiulcerosa dell’estratto LIS-014 nei ratti

Studio dell’attività antiulcerosa dell’estratto LIS-014 nei ratti

Julia Angele Raharisoa

71,90 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786630471540
71,90 €
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Sobre IBD

Lo scopo del presente studio è stato quello di valutare l’attività di LIS-014 in vivo nei ratti. Il suo effetto mucoprotettivo è stato valutato in risposta all’aggressione dell’indometacina, somministrata per via orale in modo ripetuto alla dose di 30 mg/kg al giorno. Inoltre, la sua attività antisecretoria è stata studiata mediante legatura dello piloro e, infine, la sua attività antiacida è stata valutata attraverso una reazione di neutralizzazione tra LIS-014 e il contenuto gastrico. Il LIS-014 protegge la mucosa gastrica dall’azione aggressiva dell’indometacina. Riduce la superficie delle lesioni ulcerose a livello della mucosa negli animali trattati con l’estratto rispetto al gruppo di controllo. L’effetto antisecretorio del LIS-014 è evidenziato dall’aumento del pH del succo gastrico. LIS-014 possiede inoltre un’attività antiacida ed è in grado di ridurre direttamente l’acidità del succo gastrico attraverso una reazione acido-base; negli animali trattati con l’estratto alla dose di 600 mg/kg, il pH è pari a 3,31 ± 0,13 contro 3,17 ± 0,27 per la miscela di succo gastrico con LIS-014 (P > 0,05). Queste attività potrebbero essere dovute alla presenza di flavonoidi, antociani, tannini e alcaloidi.

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