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Badanie działania przeciwwrzodowego ekstraktu LIS-014 u szczurów

Badanie działania przeciwwrzodowego ekstraktu LIS-014 u szczurów

Julia Angele Raharisoa

71,90 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786630461305
71,90 €
IVA incluido
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Celem niniejszego badania było zbadanie działania LIS-014 in vivo u szczurów. Jego działanie ochronne na błonę śluzową badano w kontekście działania indometacyny podawanej wielokrotnie doustnie w dawce 30 mg/kg dziennie. Ponadto zbadano jego działanie hamujące wydzielanie poprzez podwiązanie odźwiernika, a na koniec jego działanie zobojętniające kwas badano poprzez reakcję neutralizacji między LIS-014 a treścią żołądkową. LIS-014 chroni błonę śluzową żołądka przed działaniem indometacyny. Zmniejsza powierzchnię zmian wrzodowych w błonie śluzowej zwierząt leczonych ekstraktem w porównaniu z grupą kontrolną. Działanie hamujące wydzielanie LIS-014 przejawia się wzrostem pH soku żołądkowego. LIS-014 wykazuje również działanie przeciwwykwasowe; jest w stanie bezpośrednio obniżyć kwasowość soku żołądkowego poprzez reakcję kwasowo-zasadową u zwierząt, którym podano ekstrakt w dawce 600 mg/kg, pH wynosi 3,31 ± 0,13 w porównaniu z 3,17 ± 0,27 dla mieszaniny soku żołądkowego z LIS-014 (P > 0,05). Działania te mogą wynikać z obecności flawonoidów, antocyjanów, garbników i alkaloidów.

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