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Die Auswirkungen von Erythropoetin auf die Telomerase in malignen Zellen

Die Auswirkungen von Erythropoetin auf die Telomerase in malignen Zellen

Gil Kanfer / Meir Lahav / Orit Uziel

72,02 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630464641
72,02 €
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Die in diesem Buch beschriebene Studie untersucht die Auswirkungen von Erythropoetin auf die Telomeraseaktivität und -regulation in malignen und nicht-malignen, nicht-erythroiden Zellen. Die Exposition gegenüber Erythropoetin reguliert die Telomeraseaktivität auf posttranslationaler Ebene über die Lyn/SRC-AKT-Achse hoch. Die Hemmung der Telomerase, die zu einer Verkürzung der Telomere führt, hob diesen Effekt auf, was darauf hindeutet, dass eine Erythropoietin-Behandlung mit Anti-Telomerase-Wirkstoffen kombiniert werden könnte, um die Hochregulierung der Telomerase in den Krebszellen zu minimieren.

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