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Valutazione della genotossicità degli estratti vegetali

Valutazione della genotossicità degli estratti vegetali

Ángel Sánchez Lamar / Laura Sánchez Hechavarría / Roxana Martell Enríquez

66,66 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786209632372
66,66 €
IVA incluido
Disponible

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Sobre IBD

Questo studio ha analizzato la sicurezza genetica degli estratti idroalcolici di Calendula officinalis, Cecropia peltata e Petiveria alliacea, piante con potenziale terapeutico a Cuba per le loro proprietà antiossidanti e antinfiammatorie. L’obiettivo era valutare la loro genotossicità per escludere il rischio di mutazioni o malattie degenerative prima della loro applicazione farmacologica. Utilizzando un biomodello di DNA plasmidico ex vivo, è stata valutata la clastogenicità a concentrazioni comprese tra 1 e 1000 μg/ml. I risultati dopo 30 minuti di esposizione hanno indicato che nessuna delle specie ha causato danni al materiale genetico. Estendendo il tempo di incubazione a 4 ore alla dose massima, C. officinalis e C. peltata sono rimaste sicure, il che le conferma come candidati sicuri per futuri studi di bioattività. Al contrario, l’estratto di P. alliacea ha mostrato rotture di catena in trattamenti ≥ 2 ore a 1000 μg/ml, suggerendo la necessità di futuri test di genotossicità con biomodelli sperimentali più complicati.

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