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Bewertung der Genotoxizität von Pflanzenextrakten

Bewertung der Genotoxizität von Pflanzenextrakten

Ángel Sánchez Lamar / Laura Sánchez Hechavarría / Roxana Martell Enríquez

66,66 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786209622137
66,66 €
IVA incluido
Disponible

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Sobre IBD

In dieser Studie wurde die genetische Sicherheit von hydroalkoholischen Extrakten aus Calendula officinalis, Cecropia peltata und Petiveria alliacea untersucht, Pflanzen, die in Kuba aufgrund ihrer antioxidativen und entzündungshemmenden Eigenschaften ein therapeutisches Potenzial besitzen. Ziel war es, ihre Genotoxizität zu bewerten, um das Risiko von Mutationen oder degenerativen Erkrankungen vor ihrer pharmakologischen Anwendung auszuschließen. Ein Ex-vivo-Plasmid-DNA-Biomodell wurde verwendet, um die Klastogenität bei Konzentrationen von 1 - 1000 μg/ml zu bewerten. Die Ergebnisse nach 30-minütiger Exposition zeigten, dass keine der Spezies Schäden am genetischen Material verursachte. Durch die Verlängerung der Inkubationszeit auf 4 Stunden bei der maximalen Dosis blieben C. officinalis und C. peltata sicher, was sie als sichere Kandidaten für zukünftige Bioaktivitätsstudien bestätigt. Im Gegensatz dazu zeigte der Extrakt von P. alliacea bei Behandlungen ≥ 2 Stunden bei 1000 μg/ml Kettenbrüche, was auf die Notwendigkeit künftiger Genotoxizitätstests mit komplizierteren experimentellen Biomodellen hinweist.

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