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Avaliação da genotoxicidade de extractos de plantas

Avaliação da genotoxicidade de extractos de plantas

Ángel Sánchez Lamar / Laura Sánchez Hechavarría / Roxana Martell Enríquez

66,66 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Ciencia: cuestiones generales
ISBN:
9786209627255
66,66 €
IVA incluido
Disponible

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Sobre IBD

Este estudo investigou a segurança genética dos extractos hidroalcoólicos de Calendula officinalis, Cecropia peltata e Petiveria alliacea, plantas com potencial terapêutico em Cuba pelas suas propriedades antioxidantes e anti-inflamatórias. O objetivo era avaliar a sua genotoxicidade para excluir o risco de mutações ou doenças degenerativas antes da sua aplicação farmacológica. Utilizando um biomodelo de ADN plasmídico ex vivo, a clastogenicidade foi avaliada em concentrações de 1 - 1000 μg/ml. Os resultados após 30 minutos de exposição indicaram que nenhuma das espécies causou danos no material genético. Ao prolongar o tempo de incubação para 4 horas na dose máxima, C. officinalis e C. peltata permaneceram seguras, o que as confirma como candidatas seguras para futuros estudos de bioatividade. Em contrapartida, o extrato de P. alliacea apresentou quebras de cadeia em tratamentos ≥ 2 horas a 1000 μg/ml, sugerindo a necessidade de futuros testes de genotoxicidade com biomodelos experimentais mais complicados.

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