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Tumori neuroblastici periferici

Tumori neuroblastici periferici

Imane Tabyaoui / Nadia Tahiri Jouti

113,17 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630368321
113,17 €
IVA incluido
Disponible

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Sobre IBD

I tumori neuroblastici periferici (TNP) sono tumori solidi pediatrici estremamente eterogenei, responsabili del 15% dei decessi per cancro nei bambini. In Marocco non è stato condotto alcuno studio epidemiologico, molecolare o biologico su questi tumori. Abbiamo quindi cercato di fare il punto sui diversi dati clinici e istopatologici, nonché sui tassi di incidenza, sopravvivenza e mortalità relativi ai TNP. D’altra parte, la fase di studio molecolare ci ha permesso di implementare la tecnica dell’ibridazione in situ con fluorescenza (FISH), adottata all’unanimità a livello mondiale, al fine di determinare lo stato di amplificazione del proto-oncogene MYCN, fattore prognostico fondamentale nella scelta della strategia terapeutica. L’amplificazione del MYCN è stata riscontrata nel 27,8% dei casi. Lo studio dell’espressione del CD44 mediante immunoistochimica (IHC) ha invece rivelato che questa molecola di adesione cellulare è un potente predittore di metastasi, la cui positività è indice di assenza di invasione metastatica. I risultati ottenuti attraverso questi studi epidemiologici e analitici sono stati confrontati con i dati internazionali.

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