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Periphere Neuroblastomtumoren

Periphere Neuroblastomtumoren

Imane Tabyaoui / Nadia Tahiri Jouti

113,15 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630447323
113,15 €
IVA incluido
Disponible

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Periphere Neuroblastom-Tumoren (PNT) sind äußerst heterogene solide Tumoren im Kindesalter, die für 15 % der krebsbedingten Todesfälle bei Kindern verantwortlich sind. In Marokko wurden bislang keine epidemiologischen, molekularen oder biologischen Studien zu diesen Tumoren durchgeführt. Wir haben daher versucht, einen Überblick über die verschiedenen klinischen und histopathologischen Daten sowie über die Inzidenz-, Überlebens- und Mortalitätsraten bei PNTs zu geben. Darüber hinaus ermöglichte uns die molekulare Untersuchungsphase die Einführung der weltweit einhellig anerkannten Technik der Fluoreszenz-in-situ-Hybridisierung (FISH), um den Amplifikationsstatus des Protoonkogens MYCN zu bestimmen, einem entscheidenden Prognosefaktor bei der Wahl der Therapiestrategie. Eine MYCN-Amplifikation wurde in 27,8 % der Fälle festgestellt. Die Untersuchung der CD44-Expression mittels Immunhistochemie (IHC) ergab hingegen, dass dieses Zelladhäsionsmolekül ein starker Prädiktor für Metastasen ist, wobei eine positive Befundung ein Anzeichen für das Fehlen einer metastatischen Invasion darstellt. Die Ergebnisse dieser epidemiologischen und analytischen Studien wurden mit internationalen Daten verglichen.

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