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Tumores neuroblásticos periféricos

Tumores neuroblásticos periféricos

Imane Tabyaoui / Nadia Tahiri Jouti

113,17 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630417302
113,17 €
IVA incluido
Disponible

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Os tumores neuroblásticos periféricos (TNPs) são tumores sólidos pediátricos extremamente heterogéneos, responsáveis por 15% das mortes por cancro em crianças. Em Marrocos, não foi realizado qualquer estudo epidemiológico, molecular ou biológico relativo a estes tumores. Por isso, tentámos fazer um balanço dos diversos dados clínicos e histopatológicos, bem como das taxas de incidência, sobrevivência e mortalidade relacionadas com os TNPs. Por outro lado, a fase de estudo molecular permitiu-nos implementar a técnica de Hibridização In Situ por Fluorescência (FISH), unanimemente adotada a nível mundial, a fim de determinar o estado de amplificação do proto-oncogene MYCN, um fator prognóstico fundamental na escolha da estratégia terapêutica. A amplificação do MYCN foi detetada em 27,8% dos casos. O estudo da expressão do CD44 por imuno-histoquímica (IHC) revelou, por sua vez, que esta molécula de adesão celular é um poderoso preditor de metástases, sendo a sua positividade um sinal de ausência de invasão metastática. Os resultados obtidos através destes estudos epidemiológicos e analíticos foram comparados com dados internacionais.

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