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Nowotwory neuroblastyczne obwodowe

Nowotwory neuroblastyczne obwodowe

Imane Tabyaoui / Nadia Tahiri Jouti

113,15 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630394818
113,15 €
IVA incluido
Disponible

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Peryferyjne guzy neuroblastyczne (TNPs) to niezwykle zróżnicowane nowotwory lite u dzieci, odpowiedzialne za 15% zgonów spowodowanych rakiem w tej grupie wiekowej. W Maroku nie przeprowadzono dotychczas żadnych badań epidemiologicznych, molekularnych ani biologicznych dotyczących tych nowotworów. Postanowiliśmy zatem podsumować różne dane kliniczne i histopatologiczne, a także wskaźniki zachorowalności, przeżywalności i śmiertelności związane z TNP. Z drugiej strony faza badań molekularnych pozwoliła nam wdrożyć technikę fluorescencyjnej hybrydyzacji in situ (FISH), powszechnie stosowaną na całym świecie, w celu określenia statusu amplifikacji protoonkogenu MYCN, który jest kluczowym czynnikiem prognostycznym przy wyborze strategii terapeutycznej. Amplifikację genu MYCN stwierdzono w 27,8% przypadków. Z kolei badanie ekspresji CD44 metodą immunohistochemiczną (IHC) wykazało, że ta cząsteczka adhezyjna jest silnym predyktorem przerzutów, a jej dodatni wynik wskazuje na brak inwazji przerzutowej. Wyniki uzyskane w ramach tych badań epidemiologicznych i analitycznych porównano z danymi międzynarodowymi.

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