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Trombocitopenia induzida por heparina

Trombocitopenia induzida por heparina

Fatma Thameur / Wided Maatamri

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208986681
91,01 €
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A trombocitopenia induzida pela heparina é uma condição clínico-biológica complexa associada à terapêutica com heparina, um verdadeiro padrão anticoagulante, e paradoxalmente responsável por um importante estado pró-trombótico. Representa a complicação iatrogénica mais grave da terapêutica com heparina, que deve ser diagnosticada precocemente e tratada de forma eficaz. A sua gestão constitui uma verdadeira emergência terapêutica, exigindo a utilização de agentes antitrombóticos não heparínicos, como a danaparoide sódica e os inibidores diretos da trombina, destinados a inibir a hipercoagulabilidade induzida pela geração explosiva de trombina. O diagnóstico biológico pode por vezes ser difícil, apesar dos progressos registados na compreensão do mecanismo da doença e do desenvolvimento de testes imunológicos e funcionais, que apresentam muitas vantagens. Um dos testes funcionais mais eficazes é o ensaio de libertação de serotonina radiomarcada (RAS), que tem sido historicamente considerado o teste de referência.

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