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Trombocitopenia indotta da eparina

Trombocitopenia indotta da eparina

Fatma Thameur / Wided Maatamri

90,95 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208986728
90,95 €
IVA incluido
Disponible

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La trombocitopenia indotta da eparina è una complessa condizione clinico-biologica associata alla terapia con eparina, un vero e proprio standard anticoagulante, e paradossalmente responsabile di un importante stato pro-trombotico. Rappresenta la più grave complicanza iatrogena della terapia eparinica, che deve essere diagnosticata precocemente e trattata efficacemente. La sua gestione costituisce una vera e propria emergenza terapeutica, che richiede l’uso di agenti antitrombotici non eparinici, come il danaparoide sodico e gli inibitori diretti della trombina, progettati per inibire l’ipercoagulabilità indotta dalla generazione esplosiva di trombina. La diagnosi biologica può essere talvolta difficile, nonostante i progressi compiuti nella comprensione del meccanismo della malattia e lo sviluppo di test immunologici e funzionali, che presentano numerosi vantaggi. Uno dei test funzionali più efficaci è il test di rilascio della serotonina radiomarcata (RAS), storicamente considerato il test di riferimento.

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