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Tef1 jest białkiem wieloczynnikowym Candida albicans

Tef1 jest białkiem wieloczynnikowym Candida albicans

Justus Linden

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786203573213
91,04 €
IVA incluido
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W niniejszej pracy po raz pierwszy wykazano na poziomie komórkowym wpływ pojedynczego białka powierzchniowego na unikanie komplementu i układu odpornościowego przez Candida albicans. Tef1 (Translation Elongation Factor 1) jest białkiem moonlightingowym C. albicans. Jest ono ekspresjonowane na powierzchni komórki, wydzielane, a ponadto zlokalizowane w cytoplazmie jako czynnik translacyjny. Tef1 działa zarówno jako CRASP (białko powierzchniowe regulujące dopełniacz) bezpośrednio w miejscu ekspresji, jak i jako białko wydzielane z dala od powierzchni komórki grzyba. Tef1 wiąże się z komórkami i składnikami wrodzonego układu odpornościowego i wpływa na układ odpornościowy adaptacyjny, w szczególności na komórki B. Ogólnie rzecz biorąc, Tef1 jest wieloczynnikowym białkiem unikającym odpowiedzi immunologicznej C. albicans. Jego charakterystyka moonlighting jako białka powierzchniowego i wydzielanego pozwala Tef1 modulować zarówno wrodzoną (kaskada dopełniacza), jak i adaptacyjną odpowiedź immunologiczną (komórki B). W ten sposób Tef1 na wiele sposobów umożliwia przetrwanie C. albicans w organizmie człowieka.

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