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Tef1 è una proteina multifattoriale del Candida albicans

Tef1 è una proteina multifattoriale del Candida albicans

Justus Linden

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786203573251
91,04 €
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Nel presente lavoro viene dimostrato per la prima volta a livello cellulare il contributo di una singola proteina di superficie al complemento e all’evasione immunitaria del Candida albicans. Tef1 (Translation Elongation Factor 1) è una proteina moonlighting del C. albicans. Viene espressa sulla superficie cellulare, secreta e localizzata anche come fattore di traduzione nel citoplasma. Tef1 agisce sia come CRASP (complement regulator acquiring surface protein) direttamente nel luogo di espressione, sia come proteina secreta lontano dalla superficie cellulare del fungo. Tef1 si lega alle cellule e ai componenti del sistema immunitario innato e influenza anche il sistema immunitario adattativo, in particolare le cellule B. Nel complesso, Tef1 è una proteina multifattoriale di evasione immunitaria di C. albicans. La sua caratteristica di moonlighting come proteina di superficie e secreta consente a Tef1 di modulare sia la risposta immunitaria innata (cascata del complemento) che quella adattativa (cellule B). Tef1 consente quindi in vari modi la persistenza di C. albicans nell’organismo umano.

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