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Rozwój żelu do nosa z zolmitriptanem i niosomaliną-situ

Rozwój żelu do nosa z zolmitriptanem i niosomaliną-situ

Anilkumar Shinde / Firoj Tamboli / Karan Swami

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209329524
65,61 €
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Sobre IBD

Celem niniejszego badania było opracowanie preparatu niosomalnego żelu do nosa Zolmitriptan (ZMT) do leczenia migreny. Droga donosowa może dostarczać lek do ośrodkowego układu nerwowego (OUN) przez płaty węchowe, co pomaga ominąć barierę krew-mózg (BBB), co omija metabolizm pierwszego przejścia i w konsekwencji zwiększa biodostępność leku. Niosomy ZMT zostały przygotowane przy użyciu techniki hydratacji filmu lipidowego. Zoptymalizowana formulacja niosomalna została wykorzystana do przygotowania preparatu żelowego in situ. Opracowane preparaty scharakteryzowano pod kątem wielkości pęcherzyków, kształtu, potencjału zeta, skuteczności uwięzienia, zawartości leku i badania dyfuzji in vitro, siły mukoadhezji, badania przenikania, badań FTIR, DSC i XRD. Badania FTIR i DSC wykazały brak interakcji chemicznych między lekiem a substancjami pomocniczymi. Niosomy ZMT wykazywały rozmiar cząstek, PDI, potencjał Zeta, % skuteczność uwięzienia i zawartość leku, odpowiednio 149nm, 0,223, -28,9, 88,16±0,8% i 96,23±1,2%. Badanie dyfuzji niosomów in vitro wykazało 96,23±0,7% po 8 godzinach. Szybkość przenikania żelu niosomów in situ i czystego leku wynosiła około 98,56% i 79,46%.

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