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Przeciwnowotworowe działanie α-mangostyny na ludzkie linie komórkowe raka piersi

Przeciwnowotworowe działanie α-mangostyny na ludzkie linie komórkowe raka piersi

Mohamed Yousif Ibrahim Dafalla / Najihah Mohd Hashim

106,62 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209492204
106,62 €
IVA incluido
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W niniejszej publikacji zbadano mechanizm apoptozy wywołanej przez α-mangostynę (AM), związek ksantonowy, w liniach komórkowych MCF-7 i MDA-MB-231. Poddanie komórek działaniu AM wywołało apoptozę wraz z sygnałami przekazującymi śmierć komórkową. Sugerowano, że ten rodzaj apoptozy zachodzi zarówno poprzez szlaki zewnętrzne, jak i wewnętrzne oraz poprzez zapobieganie translokacji NF-κB z cytoplazmy do jądra komórkowego. Nasze wyniki wykazały, że AM wywołuje apoptozę obu komórek poprzez modulację białek NF-κB, Bax/Bcl-2 i HSP70 przy udziale kaspaz. Dlatego też uważa się, że AM ma znaczny potencjał w kontroli raka piersi.

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