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Effets anticancéreux de l’α-mangostine sur des lignées cellulaires humaines de cancer du sein

Effets anticancéreux de l’α-mangostine sur des lignées cellulaires humaines de cancer du sein

Mohamed Yousif Ibrahim Dafalla / Najihah Mohd Hashim

106,61 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209530265
106,61 €
IVA incluido
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Sobre IBD

Dans cet ouvrage, l’α-mangostine (AM), un composé xanthone, a été étudiée pour son mécanisme d’apoptose sur les lignées cellulaires MCF-7 et MDA-MB-231. Le traitement des cellules avec l’AM a provoqué l’apoptose avec des signaux de mort cellulaire. Ce type d’apoptose semblait se produire par les voies extrinsèque et intrinsèque et par la prévention de la translocation du NF-κB du cytoplasme vers le noyau. Nos résultats ont révélé que l’AM provoquait l’apoptose des deux cellules par la modulation des protéines NF-κB, Bax/Bcl-2 et HSP70 avec la contribution des caspases. L’AM est donc considérée comme ayant un potentiel considérable dans le contrôle du cancer du sein.

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