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Efeitos anticancerígenos da α-mangostina em linhas celulares de cancro da mama humana

Efeitos anticancerígenos da α-mangostina em linhas celulares de cancro da mama humana

Mohamed Yousif Ibrahim Dafalla / Najihah Mohd Hashim

106,62 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209477393
106,62 €
IVA incluido
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Sobre IBD

Neste livro, a α-mangostina (AM), um composto xantona, foi investigada quanto ao seu mecanismo de apoptose nas linhas celulares MCF-7 e MDA-MB-231. O tratamento das células com AM provocou apoptose com sinais de transdução de morte celular. Sugeriu-se que este tipo de apoptose ocorreu através das vias extrínseca e intrínseca e da prevenção da translocação de NF-κB do citoplasma para o núcleo. Os nossos resultados revelaram que a AM induz a apoptose de ambas as células através da modulação das proteínas NF-κB, Bax/Bcl-2 e HSP70, com a contribuição das caspases. Portanto, considera-se que a AM tem um potencial considerável no controlo do cancro da mama.

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