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Effetti antitumorali dell’α-mangostina sulle linee cellulari del cancro al seno umano

Effetti antitumorali dell’α-mangostina sulle linee cellulari del cancro al seno umano

Mohamed Yousif Ibrahim Dafalla / Najihah Mohd Hashim

106,62 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209507991
106,62 €
IVA incluido
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In questo libro, l’α-mangostina (AM), un composto xantone, è stata studiata per il suo meccanismo di apoptosi sulle linee cellulari MCF-7 e MDA-MB-231. Il trattamento delle cellule con AM ha provocato l’apoptosi con segnali di trasduzione della morte cellulare. È stato suggerito che questo tipo di apoptosi avvenga attraverso vie sia estrinseche che intrinseche e la prevenzione della traslocazione di NF-κB dal citoplasma al nucleo. I nostri risultati hanno rivelato che l’AM provoca l’apoptosi di entrambe le cellule attraverso la modulazione delle proteine NF-κB, Bax/Bcl-2 e HSP70 con il contributo delle caspasi. Pertanto, l’AM è ritenuto avere un potenziale considerevole nel controllo del cancro al seno.

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