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Potencjał osteogeniczny i adipogeniczny komórek macierzystych mezenchymalnych

Potencjał osteogeniczny i adipogeniczny komórek macierzystych mezenchymalnych

Rodrigo Paolo Abuna

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786209163869
53,66 €
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Komórki macierzyste mezenchymalne pochodzące ze szpiku kostnego (CTMs-MO) i tkanki tłuszczowej (CTMs-TA) są atrakcyjnym narzędziem do naprawy tkanki kostnej w oparciu o terapię komórkową. W niniejszym badaniu zbadano potencjał osteogeniczny i adipogeniczny CTM-MO i CTM-TA, a także wpływ komunikacji między osteoblastami i adipocytami na ekspresję fenotypu komórkowego. Wykazano, że CTM-MO są bardziej osteogeniczne, podczas gdy CTM-TA są bardziej adipogeniczne. Ponadto zaobserwowano, że komunikacja między osteoblastami a adipocytami może negatywnie wpływać na naprawę kości. W związku z tym postulujemy, że większy potencjał osteogeniczny CTMs-MO sprawia, że są one bardziej odpowiednim wyborem do indukcji naprawy kości opartej na terapii komórkowej.

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