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O efeito fisiológico das hormonas incretinas

O efeito fisiológico das hormonas incretinas

Mehrevan Abd El-moniem / Nadia Mohamed Ahmed

93,36 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Empresa y gestión
ISBN:
9786209589539
93,36 €
IVA incluido
Disponible

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Sobre IBD

As incretinas são hormonas libertadas pelo intestino em resposta à ingestão de nutrientes que potencializam a secreção de insulina estimulada pela glicose. A pesquisa sobre as incretinas foi motivada pela observação de que a administração de uma carga oral de glicose leva a uma estimulação muito maior da resposta insulínica do que a obtida quando a glicose é infundida por via intravenosa para proporcionar níveis idênticos de glicose no sangue. Esta diferença entre as duas formas de administração de glicose tem sido atribuída às hormonas incretinas, o peptídeo semelhante ao glucagon-1 (GLP-1) e o polipéptido insulinotrópico dependente de glicose (GIP), envolvidos na eliminação da glicose absorvida, através da estimulação da secreção de insulina. De facto, os agonistas do GLP-1R e os inibidores da DPP-4 têm sido amplamente utilizados com sucesso como agentes terapêuticos no tratamento da diabetes tipo 2.

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