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Novas perspetivas sobre o papel da melatonina e da desidroepiandrosterona

Novas perspetivas sobre o papel da melatonina e da desidroepiandrosterona

Abdel-Mohsen Soliman / Hanan Farouk Aly / Hoda El-Sayed Mohamed

129,99 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630203981
129,99 €
IVA incluido
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Sobre IBD

O tratamento com melatonina e/ou DHEA revelou efeitos terapêuticos, com percentagens de melhoria variáveis em todos os parâmetros bioquímicos investigados, através de uma regeneração hepática significativamente acelerada após hepatectomia parcial, atenuou a lesão hepática induzida por DMN graças às suas atividades de eliminação de ROS, modulou a lesão hepática e a fibrose hepática através da inibição de citocinas inflamatórias e do stress oxidativo, e estimulou a mitose dos hepatócitos, o que, consequentemente, conduziu à sobrevivência de ratos com elevado risco de insuficiência hepática pós-operatória após a hepatectomia. Estes resultados confirmaram as atividades de eliminação de radicais livres e antioxidantes de ambos os fármacos na melhoria da regeneração hepática após hepatectomia parcial, cirrose induzida por DMN e fígado cirrótico submetido a hepatectomia parcial.

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