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Method Development and Validation for Voriconazole Estimation

Method Development and Validation for Voriconazole Estimation

K. Vara Prasada Rao / Yarguntla Srinivasa Rao

52,20 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9783330051331
52,20 €
IVA incluido
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Sobre IBD

A rapid, sensitive, and specific RP-HPLC method with UV detection was developed and validated for the determination of voriconazole. Chromatography was performed on an Enable C18 G column (250 × 4.6 mm) in isocratic mode, using a mobile phase of methanol and acetonitrile (60:40, v/v). The flow rate was set at 1 mL/min, and the effluent was monitored at 223 nm. Chromatographic analysis revealed a main peak for voriconazole at a retention time of 2.841 minutes. Methanol was selected as the solvent for the analysis, with the λmax determined to be 223 nm. The method exhibited linearity over a concentration range of 5-30 µg/mL. Validation parameters, including linearity, range, precision, accuracy, limit of detection (LOD), and limit of quantitation (LOQ), were assessed and met the required standards.

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Otros libros del autor

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  • Desenvolvimento e validação de métodos para a estimativa do voriconazol
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    Foi desenvolvido e validado um método RP-HPLC rápido, sensível e específico com deteção por UV para a determinação do voriconazol. A cromatografia foi efectuada numa coluna Enable C18 G (250 × 4,6 mm) em modo isocrático, utilizando uma fase móvel de metanol e acetonitrilo (60:40, v/v). O caudal foi fixado em 1 mL/min e o efluente foi monitorizado a 223 nm. A análise cromatográf...
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