La protéine associée à Yes (YAP) en tant que prédicteur pronostique dans le cancer de la bouche

La protéine associée à Yes (YAP) en tant que prédicteur pronostique dans le cancer de la bouche

Dineshkumar Thayalan / Indumathi Nandhakumar

65,68 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
ISBN:
9786209484896
65,68 €
IVA incluido
Disponible

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Cette étude explore l’expression de la protéine associée à Yes (YAP), un effecteur clé de la voie Hippo, à travers le spectre de la carcinogenèse buccale. En utilisant l’immunohistochimie sur des échantillons de muqueuse buccale normale, de leucoplasie et de carcinome épidermoïde buccal (OSCC) provenant de sources éthiques, nous avons observé une augmentation claire et progressive de la coloration de la protéine YAP du tissu sain à la dysplasie et enfin à l’OSCC. Les lésions dysplasiques ont montré des augmentations progressives de l’intensité de la YAP en corrélation avec la sévérité, tandis que l’OSCC a montré l’expression la plus élevée. Les colorations nucléaires et cytoplasmiques étaient évidentes, la positivité nucléaire (>10%) soulignant le rôle transcriptionnel actif de YAP dans la promotion de la croissance cellulaire et de la transformation maligne. Ces résultats suggèrent que YAP est un biomarqueur important et un moteur potentiel de la progression du cancer de la bouche.

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