A Proteína Associada ao Sim (YAP) como Preditor de Prognóstico no Cancro Oral

A Proteína Associada ao Sim (YAP) como Preditor de Prognóstico no Cancro Oral

Dineshkumar Thayalan / Indumathi Nandhakumar

65,61 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
ISBN:
9786209490019
65,61 €
IVA incluido
Disponible

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Sobre IBD

Este estudo explora a expressão da proteína associada a Yes (YAP), um efector chave da via Hippo, ao longo do espetro da carcinogénese oral. Utilizando imunohistoquímica em amostras de origem ética de mucosa oral normal, leucoplasia e carcinoma de células escamosas oral (CCEO), observámos um aumento claro e progressivo da coloração de YAP do tecido saudável para a displasia e, finalmente, para o CCEO. As lesões displásicas apresentaram aumentos graduais na intensidade de YAP, correlacionados com a gravidade, enquanto o CCEO apresentou a expressão mais elevada. Tanto a coloração nuclear como a citoplasmática foram evidentes, com a positividade nuclear (>10%) a realçar o papel ativo de transcrição de YAP na promoção do crescimento celular e da transformação maligna. Estes resultados sugerem que a YAP é um biomarcador significativo e um potencial impulsionador da progressão do cancro oral.

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