Ja-assoziiertes Protein (YAP) als prognostischer Prädiktor bei Mundkrebs

Ja-assoziiertes Protein (YAP) als prognostischer Prädiktor bei Mundkrebs

Dineshkumar Thayalan / Indumathi Nandhakumar

65,68 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
ISBN:
9786209482335
65,68 €
IVA incluido
Disponible

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Sobre IBD

In dieser Studie wird die Expression des Yes-assoziierten Proteins (YAP), eines Schlüsseleffektors des Hippo-Signalwegs, im gesamten Spektrum der oralen Karzinogenese untersucht. Mit Hilfe der Immunhistochemie an ethisch einwandfreien Proben von normaler Mundschleimhaut, Leukoplakie und oralen Plattenepithelkarzinomen (OSCC) beobachteten wir einen deutlichen, progressiven Anstieg der YAP-Färbung von gesundem Gewebe zu Dysplasie und schließlich zu OSCC. Dysplastische Läsionen zeigten eine schrittweise Zunahme der YAP-Intensität, die mit dem Schweregrad korrelierte, während OSCC die höchste Expression aufwies. Es wurden sowohl nukleäre als auch zytoplasmatische Färbungen festgestellt, wobei die nukleäre Positivität (>10 %) die aktive transkriptionelle Rolle von YAP bei der Förderung des Zellwachstums und der malignen Transformation unterstreicht. Diese Ergebnisse deuten darauf hin, dass YAP ein signifikanter Biomarker und potenzieller Treiber für das Fortschreiten von Mundkrebs ist.

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