La proteina associata a Sì (YAP) come predittore prognostico nel cancro orale

La proteina associata a Sì (YAP) come predittore prognostico nel cancro orale

Dineshkumar Thayalan / Indumathi Nandhakumar

65,61 €
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Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
ISBN:
9786209497698
65,61 €
IVA incluido
Disponible

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Questo studio esplora l’espressione della proteina associata a Yes (YAP), un effettore chiave della via di Hippo, attraverso lo spettro della carcinogenesi orale. Utilizzando l’immunoistochimica su campioni di mucosa orale normale, leucoplachia e carcinoma orale a cellule squamose (OSCC), abbiamo osservato un chiaro e progressivo aumento della colorazione di YAP dal tessuto sano alla displasia e infine all’OSCC. Le lesioni displastiche hanno mostrato un aumento graduale dell’intensità di YAP correlato alla gravità, mentre l’OSCC ha mostrato la massima espressione. Sono state evidenziate colorazioni sia nucleari che citoplasmatiche, con una positività nucleare (>10%) che evidenzia il ruolo trascrizionale attivo di YAP nel promuovere la crescita cellulare e la trasformazione maligna. Questi risultati suggeriscono che YAP è un biomarcatore significativo e un potenziale driver della progressione del cancro orale.

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