Białko związane z Yes (YAP) jako czynnik prognostyczny w raku jamy ustnej

Białko związane z Yes (YAP) jako czynnik prognostyczny w raku jamy ustnej

Dineshkumar Thayalan / Indumathi Nandhakumar

65,61 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
ISBN:
9786209495137
65,61 €
IVA incluido
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Sobre IBD

W niniejszym badaniu zbadano ekspresję białka związanego z Yes (YAP), kluczowego efektora szlaku Hippo, w całym spektrum kancerogenezy jamy ustnej. Stosując immunohistochemię na etycznie pobranych próbkach prawidłowej błony śluzowej jamy ustnej, leukoplakii i raka płaskonabłonkowego jamy ustnej (OSCC), zaobserwowaliśmy wyraźny, postępujący wzrost barwienia YAP od zdrowej tkanki do dysplazji i ostatecznie do OSCC. Zmiany dysplastyczne wykazywały stopniowy wzrost intensywności YAP korelujący z ciężkością, podczas gdy OSCC wykazywał najwyższą ekspresję. Widoczne było zarówno barwienie jądrowe, jak i cytoplazmatyczne, przy czym dodatni wynik jądrowy (>10%) podkreślał aktywną rolę transkrypcyjną YAP w promowaniu wzrostu komórek i złośliwej transformacji. Odkrycia te sugerują, że YAP jest znaczącym biomarkerem i potencjalnym czynnikiem napędzającym progresję raka jamy ustnej.

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