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Dupla ação farmacológica do sistema de administração de fármacos

Dupla ação farmacológica do sistema de administração de fármacos

Anupam Singh Bhaodouriya / Manoj Kumar Mishra / Pramod Kumar Biswal

73,64 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786630023176
73,64 €
IVA incluido
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Sobre IBD

O objetivo da presente investigação foi desenvolver um sistema de libertação bifásica (rápida/lenta) para o diclofenaco sódico. Foi preparado, por compressão direta, um comprimido de dois componentes constituído por um núcleo de libertação prolongada e um revestimento de libertação imediata. Tanto o núcleo como o revestimento continham um fármaco modelo (diclofenaco sódico). O efeito de libertação prolongada foi alcançado com um polímero (celulose microcristalina) para modular a libertação do fármaco. O perfil de libertação in vitro destes comprimidos revelou o comportamento de libertação bifásica pretendido: o diclofenaco sódico contido no componente de libertação rápida dissolveu-se em 2 minutos, enquanto o fármaco no núcleo do comprimido foi libertado em momentos diferentes (≈16 ou 924 horas), dependendo da composição da matriz do comprimido. Com base nos parâmetros cinéticos de libertação calculados, pode concluir-se que o núcleo microcristalino era adequado para proporcionar uma libertação constante e controlada (de ordem zero) durante um longo período de tempo.

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