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Doppia azione farmacologica del sistema di somministrazione dei farmaci

Doppia azione farmacologica del sistema di somministrazione dei farmaci

Anupam Singh Bhaodouriya / Manoj Kumar Mishra / Pramod Kumar Biswal

73,64 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786630018059
73,64 €
IVA incluido
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Lo scopo della presente ricerca era quello di sviluppare un sistema di rilascio bifasico (rapido/lento) per il diclofenac sodico. È stata preparata, mediante compressione diretta, una compressa a doppio strato costituita da un nucleo a rilascio prolungato e da un rivestimento a rilascio immediato. Sia il nucleo che il rivestimento contenevano un principio attivo modello (diclofenac sodico). L’effetto a rilascio prolungato è stato ottenuto utilizzando un polimero (cellulosa microcristallina) per modulare il rilascio del farmaco. Il profilo di rilascio in vitro di queste compresse ha mostrato il comportamento di rilascio bifasico desiderato: il diclofenac sodico contenuto nella componente a rilascio rapido si è dissolto entro 2 minuti, mentre il farmaco nel nucleo della compressa è stato rilasciato in tempi diversi (≈16 o 924 ore), a seconda della composizione della matrice della compressa. Sulla base dei parametri cinetici di rilascio calcolati, si può concludere che il nucleo microcristallino era adatto a fornire un rilascio costante e controllato (di ordine zero) per un lungo periodo di tempo.

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