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Antiaggregierende Wirkung von Extrakten aus fünf Heilpflanzen

Antiaggregierende Wirkung von Extrakten aus fünf Heilpflanzen

Mohammed El Haouari

65,55 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786209253447
65,55 €
IVA incluido
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Blutplättchen (oder Thrombozyten) spielen eine zentrale Rolle bei den Hämostasemechanismen und der Aufrechterhaltung der Gefäßintegrität. Ihre übermäßige Aktivierung kann jedoch zur Entstehung von Herz-Kreislauf-Erkrankungen wie Thrombosen und Arteriosklerose beitragen. Ziel dieser Arbeit ist es, in vitro die antiaggregative Wirkung von Extrakten aus fünf marokkanischen Heilpflanzen zu untersuchen: Arbutus unedo, Urtica dioica, Petroselinum Crispum, Cistus ladaniferus und Equisetum arvense bei Ratten. Die erhaltenen Ergebnisse zeigen, dass die getesteten Extrakte dosisabhängig die Thrombozytenaggregation hemmen. Bei 10 mg/ml variiert der Grad der Aggregationshemmung für Thrombin zwischen 28,1 % und 78,1 % und für ADP zwischen 41,5 % und 82,24 %. Die berechneten IC50-Werte für die getesteten Extrakte schwanken zwischen 5,68 und 15,5 mg/ml. Darüber hinaus reduzierten die getesteten Pflanzen die Geschwindigkeit der Blutplättchenaggregation deutlich. Diese Effekte würden mit dem Vorhandensein von Wirkstoffen mit antiaggregativer Wirkung in den Extrakten der getesteten Pflanzen zusammenhängen, die für die Behandlung bestimmter Herz-Kreislauf-Erkrankungen wie Arteriosklerose von Vorteil sein könnten.

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