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Stellenwert der Durchflusszytometrie bei der Untersuchung von Thrombozyten

Stellenwert der Durchflusszytometrie bei der Untersuchung von Thrombozyten

Amel Ben Smida / Wided Maatamri

65,93 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786202470438
65,93 €
IVA incluido
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Die Durchflusszytometrie ist eine empfindliche Technik, die in mehreren Bereichen, nämlich der Onkohämatologie, der Immunhämatologie und der Hämostase, allgegenwärtig ist. Die Untersuchung der Thrombozytenfunktion ermöglicht die Erkennung von Erbkrankheiten, die mit Glykoproteinstörungen verbunden sind, wie die Glanzmann-Thrombasthenie und das Bernard-Soulier-Syndrom. Die Analyse beruht auf der Passage vor einem oder mehreren Lasern nach Markierung mit verschiedenen Fluorochromen. Thrombozyten durchlaufen während ihrer Aktivierung morphologische Veränderungen und Veränderungen in der Expression bestimmter Glykoproteine, die auf ihrer Oberfläche nativ vorhanden sind oder sich in ihren Granula befinden. Die Durchflusszytometrie ist die Technik der Wahl für die Untersuchung von Thrombozytenveränderungen, da sie eine ausgezeichnete Empfindlichkeit und Reproduzierbarkeit aufweist, aber eine Standardisierung der Techniken und einen leistungsfähigen Manipulator erfordert.

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