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Rola cytometrii przepływowej w badaniu płytek krwi

Rola cytometrii przepływowej w badaniu płytek krwi

Amel Ben Smida / Wided Maatamri

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786202470476
65,80 €
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Sobre IBD

Cytometria przepływowa jest czułą techniką, która jest szeroko stosowana w wielu dziedzinach, w tym w onkohematologii, immunohematologii i hemostazie. Badanie funkcji płytek krwi umożliwia wykrywanie chorób dziedzicznych związanych z zaburzeniami glikoprotein, takich jak trombastenia Glanzmanna i zespół Bernarda Souliera. Analiza opiera się na przejściu płytek krwi przed jednym lub kilkoma laserami po wyznakowaniu różnymi fluorochromami. Płytki krwi ulegają zmianom morfologicznym podczas aktywacji, a także zmianom w ekspresji niektórych glikoprotein, zarówno obecnych na ich powierzchni w stanie natywnym, jak i zawartych w ich granulkach. Technika ta może być również stosowana do monitorowania pacjentów poddawanych terapii przeciwpłytkowej oraz do wykrywania chorób immunologicznych, takich jak małopłytkowość indukowana heparyną i immunologiczna plamica małopłytkowa. Cytometria przepływowa jest techniką z wyboru do badania zmian płytek krwi, oferując doskonałą czułość i powtarzalność, ale wymaga standardowych technik i operatora o wysokiej wydajności.

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