Inicio > Matemáticas y ciencia > Biologia, ciencias de la vida > Regulierung der Fortbewegung durch Theta-Oszillationen im Hippocampus
Regulierung der Fortbewegung durch Theta-Oszillationen im Hippocampus

Regulierung der Fortbewegung durch Theta-Oszillationen im Hippocampus

Franziska Bender

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208983475
85,68 €
IVA incluido
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Theta-Oszillationen im Hippocampus unterstützen die Kodierung der Position eines Tieres während der räumlichen Navigation, und die Theta-Frequenz korreliert mit der Laufgeschwindigkeit. Allerdings blieb lange Zeit unklar, ob Theta-Oszillationen im Hippocampus die Fortbewegung regulieren. Erst seit kurzem können bestimmte Hirnbahnen mit hoher räumlicher und zeitlicher Präzision mithilfe der Optogenetik manipuliert werden. In dieser Studie wurden Theta-Oszillationen im Hippocampus durch optogenetische Stimulation von Schrittmacherzellen im medialen Septum, die mit Theta-Frequenzen zum Hippocampus projizieren, synchronisiert. Die Synchronisation führte zu einer geringeren Variabilität der Theta-Amplitude, was eine langsamere und regelmäßigere Laufgeschwindigkeit zur Folge hatte. Die pharmakologische oder optogenetische Hemmung des wichtigsten subkortikalen Outputs des Hippocampus zum lateralen Septum verhinderte die Verhaltenswirkung der Synchronisation. Zusammenfassend liefern die Ergebnisse Hinweise darauf, dass Theta-Oszillationen im Hippocampus die Bewegungsgeschwindigkeit über einen lateralen Septum-Pfad regulieren können.

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