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Régulation de la locomotion par les oscillations thêta de l’hippocampe

Régulation de la locomotion par les oscillations thêta de l’hippocampe

Franziska Bender

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208983482
85,68 €
IVA incluido
Disponible

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Les oscillations thêta de l’hippocampe soutiennent l’encodage de la position d’un animal pendant la navigation spatiale et la fréquence thêta est corrélée à la vitesse de course. Cependant, la question de savoir si les oscillations thêta de l’hippocampe régulent la locomotion restait en suspens depuis longtemps. Ce n’est que récemment que des voies cérébrales distinctes peuvent être manipulées avec une grande précision spatiale et temporelle à l’aide de l’optogénétique. Dans cette étude, les oscillations thêta de l’hippocampe ont été entraînées par l’excitation optogénétique des cellules pacemakers du septum médian projetant vers l’hippocampe à des fréquences thêta. L’entraînement a favorisé une plus faible variabilité de l’amplitude thêta, ce qui a entraîné une vitesse de course plus lente et plus régulière. L’inhibition pharmacologique ou optogénétique de la principale sortie sous-corticale de l’hippocampe vers le septum latéral a empêché l’effet comportemental de l’entraînement. En conclusion, ces résultats démontrent que les oscillations thêta de l’hippocampe peuvent réguler la vitesse locomotrice via une voie du septum latéral.

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