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Regulação da locomoção por oscilações teta do hipocampo

Regulação da locomoção por oscilações teta do hipocampo

Franziska Bender

85,71 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208983512
85,71 €
IVA incluido
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Sobre IBD

As oscilações teta do hipocampo apoiam a codificação da posição de um animal durante a navegação espacial e a frequência teta está correlacionada com a velocidade de corrida. No entanto, se as oscilações teta do hipocampo regulam a locomoção permaneceu uma questão de longa data. Só recentemente é que vias cerebrais distintas podem ser manipuladas com alta precisão espacial e temporal usando optogenética. Neste estudo, as oscilações teta do hipocampo foram sincronizadas por excitação optogenética das células marcapasso do septo medial que se projetam para o hipocampo em frequências teta. A sincronização promoveu uma menor variabilidade da amplitude teta, o que mediou uma velocidade de corrida mais lenta e regular. A inibição farmacológica ou optogenética da principal saída subcortical do hipocampo, para o septo lateral, impediu o efeito comportamental da sincronização. Em conclusão, os resultados fornecem evidências de que as oscilações teta do hipocampo podem regular a velocidade locomotora através de uma via do septo lateral.

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