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Projektowanie, synteza i ocena niektórych nowych związków heterocyklicznych

Projektowanie, synteza i ocena niektórych nowych związków heterocyklicznych

Parag Rabara / Shashikant Pattan

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208791964
54,97 €
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W niniejszej pracy badawczej zsyntetyzowano nową serię pochodnych 1,3,4-oksadiazolu i pirazolonu. Pochodne 2-merkapto-1,3,4-oksadiazolu zsyntetyzowano poprzez reakcję odpowiedniego hydrazydu kwasu z disiarczkiem węgla, a następnie kondensację aktywnego atomu wodoru grupy 2-merkapto 5-arylo-2-merkapto-1,3,4-oksadiazolu z 2-chloro pirydyną, 4-chloro aniliną i epichlorohydryną w celu otrzymania pochodnych 5-arylo-2-(podstawionych arylo ylthio)-1,3,4-oksadiazolu (A1-3, B1-4). Pochodne 5-(podstawionych arylo)-1,3,4-oksadiazolu zsyntetyzowano w reakcji hydrazydu kwasu salicylowego z kwasem aromatycznym, otrzymując pochodne 5-(2-hydroksyfenylo)-2-arylo-1,3,4-oksadiazolu (A4-6): Pochodne 3-metylo-pirazolo-5(4H)-onu zsyntetyzowano w reakcji odpowiedniego hydrazydu kwasu z acetylooctanem etylu dając 1-(podstawiony aryl)-3-metylo-1H-pirazolo-5(4H)-on. Następnie skondensowano aktywny atom wodoru -CH2- pirazolonu z hydrazyną kwasu izonikotynowego / kwasem p-amino salicylowym / sulfanilamidem / 5-amino tetrazolem / hydrazydem kwasu pirazynowego / 2-amino pirazyną, otrzymując odpowiednie pochodne pirazolonu (A7-11, B5-9).

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