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Design, Synthese und Bewertung einiger neuartiger heterocyclischer Verbindungen

Design, Synthese und Bewertung einiger neuartiger heterocyclischer Verbindungen

Parag Rabara / Shashikant Pattan

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208791988
55,04 €
IVA incluido
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In der vorliegenden Forschungsarbeit wurde eine neue Reihe von 1,3,4-Oxadiazol- und Pyrazolonderivaten synthetisiert. 2-Mercapto-1,3,4-oxadiazol-Derivate wurden durch Reaktion des entsprechenden Säurehydrazids mit Schwefelkohlenstoff und anschließende Kondensation des aktiven Wasserstoffatoms der 2-Mercaptogruppe von 5-Aryl-2-mercapto-1,3,4-oxadiazol mit 2-Chlorpyridin, 4-Chloranilin und Epichlorhydrin, um 5-Aryl-2-(substituiertes Arylthio)-1,3,4-oxadiazol-Derivate (A1-3, B1-4) zu erhalten. 5-(substituiertes Aryl)-1,3,4-Oxadiazol-Derivate wurden durch Reaktion von Salicylsäurehydrazid mit aromatischer Säure synthetisiert, um 5-(2-Hydroxyphenyl)-2-Aryl-1,3,4-Oxadiazol-Derivate (A4-6) zu erhalten: 3-Methyl-pyrazol-5(4H)-on-Derivate wurden durch Reaktion des entsprechenden Säurehydrazids mit Ethylacetoacetat synthetisiert, um 1-(substituiertes Aryl)-3-methyl-1H-pyrazol-5(4H)-on zu erhalten. Anschließend wurde das aktive Wasserstoffatom von -CH2- des Pyrazolons mit Isonicotinsäurehydrazin/p-Aminosalicylsäure/Sulfanilamid/5-Aminotetrazol/ Pyrazinoessigsäurehydrazid/2-Aminopyrazin kondensiert, um die entsprechenden Pyrazolonderivate (A7-11, B5-9) zu erhalten.

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