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Nuovi curcuminoidi inibitori della neuraminidasi dell’influenza A (H1N1)

Nuovi curcuminoidi inibitori della neuraminidasi dell’influenza A (H1N1)

Tung Bui Thanh

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208474737
60,13 €
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La comparsa di virus influenzali resistenti ai farmaci e la minaccia di pandemie evidenziano la necessità di nuovi ed efficaci agenti antivirali. Nell’ambito di un programma di screening anti-influenzale di prodotti naturali attualmente in corso, alcuni curcuminoidi sono stati isolati da un estratto metanolico di Curcuma longa L. Tutti i composti hanno mostrato forti effetti inibitori sulle neuraminidasi di due ceppi virali influenzali, H1N1 e H9N2. Inoltre, hanno mostrato una significativa attività inibitoria contro le neuraminidasi del nuovo virus influenzale H1N1 (WT) e del nuovo virus H1N1 resistente all’oseltamivir (mutante H274Y) espressi nelle cellule 293T. Inoltre, sono state studiate le relazioni dettagliate tra struttura e attività dei composti. Questi risultati suggeriscono che i curcuminoidi della C. longa potrebbero essere potenziali molecole supplementari nella lotta contro l’influenza A (H1N1).

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