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Nowe kurkuminoidy hamujące neuraminidazę wirusa grypy A (H1N1)

Nowe kurkuminoidy hamujące neuraminidazę wirusa grypy A (H1N1)

Tung Bui Thanh

60,13 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208477295
60,13 €
IVA incluido
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Sobre IBD

Pojawienie się lekoopornych wirusów grypy i zagrożenie pandemią podkreślają potrzebę opracowania nowych i skutecznych środków przeciwwirusowych. W ramach trwającego programu badań przesiewowych produktów naturalnych pod kątem działania przeciwgrypowego, z ekstraktu metanolowego Curcuma longa L. wyizolowano niektóre kurkuminoidy. Wszystkie związki wykazywały silne działanie hamujące neuraminidazy dwóch szczepów wirusa grypy, H1N1 i H9N2. Ponadto wykazywały one znaczną aktywność hamującą wobec neuraminidaz nowego wirusa grypy H1N1 (WT) i nowego wirusa H1N1 opornego na oseltamivir (mutant H274Y) wyrażanego w komórkach 293T. Ponadto zbadano szczegółowe zależności między strukturą a aktywnością tych związków. Wyniki te sugerują, że kurkuminoidy z C. longa mogą być potencjalnymi cząsteczkami uzupełniającymi w walce z grypą A (H1N1).

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