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Neuroochronne działanie adenozyny N6-izopentanylu

Neuroochronne działanie adenozyny N6-izopentanylu

Anand VijayaKumar Parul Ramkrishnan / Kumari Sonal Gupta / Sangmeshwar Baburao Shinde

73,46 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209675034
73,46 €
IVA incluido
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Choroba Alzheimera (AD), najczęstsza forma demencji, to postępujące zaburzenie neurodegeneracyjne, które dotyka miliony ludzi, zwłaszcza w starzejącej się populacji. Charakteryzująca się blaszkami starczymi, złogami beta-amyloidu (Aβ), splątkami neurofibrylarnymi oraz selektywną utratą neuronów, AD prowadzi do stopniowego pogorszenia funkcji poznawczych, pamięci i codziennego funkcjonowania. Choć obecne metody leczenia koncentrują się głównie na łagodzeniu objawów poprzez modulację poziomów neurotransmiterów, w niewielkim stopniu hamują one postęp choroby.N6-izopentenロードadenozyna (iPA), naturalnie występująca pochodna purynowa, daje nadzieję jako nowatorskie podejście terapeutyczne w chorobach neurodegeneracyjnych, takich jak Alzheimer. Dzięki swoim niezwykłym właściwościom przeciwzapalnym, przeciwutleniającym i antyapoptotycznym, iPA wykazuje zdolność do modulowania kluczowych szlaków sygnałowych, które wspierają przetrwanie i plastyczność neuronów. Badania przedkliniczne wykazały jej potencjał do zmniejszania stanów zapalnych, łagodzenia uszkodzeń neuronów oraz poprawy funkcji poznawczych w modelach zwierzęcych, dając nową nadzieję pacjentom z AD.

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