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Effetto neuroprotettivo dell’adenosina N6- isopentanile

Effetto neuroprotettivo dell’adenosina N6- isopentanile

Anand VijayaKumar Parul Ramkrishnan / Kumari Sonal Gupta / Sangmeshwar Baburao Shinde

73,46 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786138382379
73,46 €
IVA incluido
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La malattia di Alzheimer (AD), la forma più comune di demenza, è un disturbo neurodegenerativo progressivo che colpisce milioni di persone, in particolare la popolazione anziana. Caratterizzato da placche senili, depositi di beta-amiloide (Aβ), ammassi neurofibrillari e perdita neuronale selettiva, l’AD porta a un graduale declino delle funzioni cognitive, della memoria e delle attività quotidiane. Sebbene i trattamenti attuali mirino principalmente al sollievo sintomatico modulando i livelli dei neurotrasmettitori, non contribuiscono quasi per nulla ad arrestare la progressione della malattia.La N6-isopenteniladenosina (iPA), un derivato purinico di origine naturale, rappresenta un approccio terapeutico promettente per le malattie neurodegenerative come l’Alzheimer. Grazie alle sue straordinarie proprietà antinfiammatorie, antiossidanti e antiapoptotiche, è stato dimostrato che l’iPA modula vie di segnalazione chiave che promuovono la sopravvivenza e la plasticità neuronale. Studi preclinici hanno dimostrato il suo potenziale nel ridurre l’infiammazione, attenuare il danno neuronale e migliorare la funzione cognitiva in modelli animali, offrendo una nuova speranza per i pazienti affetti da AD.

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