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HIF-1 come potenziale bersaglio farmacologico per i tumori solidi

HIF-1 come potenziale bersaglio farmacologico per i tumori solidi

Kinjal Majithiya / Palak Guralwar / Sonal Manohar

75,58 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786208276386
75,58 €
IVA incluido
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L’ipossia è una caratteristica microambientale tipica di molti tumori solidi. HIF-1 è il regolatore chiave della risposta del tumore in crescita all’ipossia. I livelli della subunità HIF-1α aumentano in ambienti ipossici, quando gli oncogeni sono attivati e/o quando i geni soppressori tumorali sono inattivati, il che è necessario per la funzione di HIF-1 nei tumori. L’HIF-1 attiva i geni che consentono alle cellule di un tumore solido di prosperare nell’ambiente ipossico nocivo del tumore attraverso il raggiungimento di numerosi segni distintivi del cancro.Questo libro analizza la regolazione e il ruolo dell’HIF-1 nella segnalazione oncogenica. Il libro sarà utile come testo di riferimento per gli studenti dei corsi di laurea e post-laurea in Scienze Biologiche, Scienze Biomediche e per coloro che hanno un interesse particolare per la Biologia del Cancro.

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