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HIF-1 als potenzielles Medikamentenziel für solide Tumoren

HIF-1 als potenzielles Medikamentenziel für solide Tumoren

Kinjal Majithiya / Palak Guralwar / Sonal Manohar

75,64 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786208276355
75,64 €
IVA incluido
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Sobre IBD

Hypoxie ist ein typisches Merkmal der Mikroumgebung vieler solider Tumoren. HIF-1 ist der Hauptregulator für die Reaktion des wachsenden Tumors auf Hypoxie. Der Spiegel der HIF-1α-Untereinheit steigt in hypoxischen Umgebungen an, wenn Onkogene aktiviert und/oder Tumorsuppressorgene inaktiviert werden; dies ist für die Funktion von HIF-1 in Tumoren notwendig. HIF-1 schaltet Gene ein, die es den Zellen eines soliden Tumors ermöglichen, in der schädlichen hypoxischen Tumorumgebung zu gedeihen und zahlreiche Krebsmerkmale zu entwickeln.In diesem Buch werden die Regulierung und die Rolle von HIF-1 bei der onkogenen Signalübertragung erläutert. Das Buch ist ein nützliches Nachschlagewerk für Studenten der Biowissenschaften und der Biomedizin sowie für all jene, die ein besonderes Interesse an der Krebsbiologie haben.

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