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Gegenwärtiges und zukünftiges Potenzial des gastroretentiven Arzneimittel- verabreichungssystems

Gegenwärtiges und zukünftiges Potenzial des gastroretentiven Arzneimittel- verabreichungssystems

Meher Priya Sharma / Sneha Anand / Sonia Narwal

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208800444
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Sobre IBD

Gastroretentive Arzneimittelabgabesysteme sollen die Verweildauer im Magen verlängern und eine kontrollierte oder anhaltende Wirkstofffreisetzung ermöglichen. Dieser Ansatz erhöht die Wirkstoffkonzentration am Zielort, was die Bioverfügbarkeit verbessern und die erforderliche Dosierung verringern kann. In den letzten Jahrzehnten wurden verschiedene Technologien entwickelt, die jeweils unterschiedliche Mechanismen nutzen, um die Verweildauer von Arzneimitteln im Magen-Darm-Trakt zu verlängern und gleichzeitig die Bioverfügbarkeit zu optimieren. Es wurden umfangreiche Forschungsarbeiten zu verschiedenen gastroretentiven Strategien durchgeführt, darunter schwimmfähige, mukoadhäsive, quellfähige, magnetische, nanofaserige, hochdichte und expandierbare Systeme. Dieses Buch befasst sich mit den Fortschritten dieser Technologien, ihrer klinischen Bedeutung und den Verabreichungsmethoden für Arzneimittel und zeigt ihre vielversprechenden künftigen Anwendungen auf.

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