Inicio > Matemáticas y ciencia > Biologia, ciencias de la vida > Badanie mechanizmów cytotoksycznych w ludzkich komórkach NK
Badanie mechanizmów cytotoksycznych w ludzkich komórkach NK

Badanie mechanizmów cytotoksycznych w ludzkich komórkach NK

Christian Backes

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208986032
101,44 €
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Komórki NK (natural killer) są częścią wrodzonego układu odpornościowego. Tworzą one synapsę immunologiczną (IS) z zainfekowanymi lub nowotworowymi komórkami docelowymi i zabijają je za pomocą receptorów śmierci (ligand Fas CD95 i receptor Fas CD178) lub poprzez uwalnianie perforiny i granzymu z granulek litycznych. Wiązanie Fas-FasL indukuje apoptozę. Uwalnianie perforiny może wywołać bezpośrednią lizę komórek docelowych (nekrozę) lub doprowadzić do przeniknięcia granzymów do komórki docelowej, co indukuje apoptozę. Oba rodzaje śmierci komórek docelowych zależne od NK zostały opisane w literaturze, jednak analizy populacyjne zostały przeprowadzone wyłącznie za pomocą testów końcowych. Dynamiczna regulacja zależnej od NK apoptozy i nekrozy komórek docelowych na poziomie pojedynczych komórek nie została jeszcze zbadana. Aby zbadać dynamiczne procesy zachodzące w pojedynczych komórkach, komórki docelowe, które mogą zostać zabite przez ludzkie komórki NK, zostały stabilnie transfekowane czujnikiem śmierci komórkowej. Test ten pozwala na klasyfikację apoptozy i nekrozy pojedynczych komórek na podstawie różnych wzorów fluorescencji czujnika opartego na FRET.

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