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Antimykotische Wirkung von Tintenfischtintenextrakt gegen Lungenaspergillose

Antimykotische Wirkung von Tintenfischtintenextrakt gegen Lungenaspergillose

Enas Ali / Nevien Ahmed / Sohair Fahmy

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786209597886
67,11 €
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Der häufige Einsatz von Antibiotika, Kortikosteroiden, Antitumormitteln und Immunsuppressiva erhöht die Morbidität der invasiven pulmonalen Aspergillose (IPA). Die Tintensekretion von Weichtierarten wurde als eine der neuen Quellen für bioaktive Verbindungen identifiziert. Die vorliegende Studie zeigte eine gute in vitro- und in vivo-Antimykotika-Aktivität von Sepia-Tintenextrakt (IE) gegen Aspergillus fumigatus. Im Vergleich zur IPA-Gruppe hatten die mit IE, AMB und AMB + IE behandelten Tiere eine Verringerung der pulmonalen Pilzlast um 67,80 %, 83,41 % bzw. 72,68 %. Die Ergebnisse der In-vivo- und In-vitro-Studien zeigen, dass IE durch die Verringerung von oxidativem Stress eine therapeutische Wirkung gegen invasive pulmonale Aspergillose hat.

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